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Richard Whitley, a University of Alabama at Birmingham researcher and pioneer in antiviral therapy, was the first to successfully use the drug in humans.

Aciclovir is the INN and BAN while acyclovir is the USAN and former BAN.

Nucleosides isolated from a Caribbean sponge, Cryptotethya crypta, were the basis for the synthesis of aciclovir.

Elion was awarded the 1988 Nobel Prize in Medicine, partly for the development of aciclovir.

It is also effective in systemic or traumatic herpes infections, eczema herpeticum and Herpes simplex meningitis.

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Aciclovir has a high distribution rate; protein binding is reported to range from 9 to 33%.

Since discovery in mid 1970s, it is being used as an effective drug for the treatment of infections caused by most known species of the Herpes virus family including Herpes zoster & Varicella zoster viruses.

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